General Information

  • ID:  hor006259
  • Uniprot ID:  Q13519
  • Protein name:  Neuropeptide 1
  • Gene name:  PNOC
  • Organism:  Homo sapiens (Human)
  • Family:  Opioid neuropeptide precursor family
  • Source:  Human
  • Expression:  Predominantly expressed in the brain and spinal cord. Also expressed and secreted by peripheral blood neutrophils following degranulation.
  • Disease:  Diseases associated with PNOC include Postpartum Depression and Neonatal Abstinence Syndrome.
  • Comments:  NA
  • Taxonomy:  Homo (genus), Homininae (subfamily), Hominidae (family), Hominoidea (superfamily), Catarrhini (parvorder), Simiiformes (infraorder), Haplorrhini (suborder), Primates (order), Euarchontoglires (superorder), Boreoeutheria, Eutheria, Theria, Mammalia (class), Amniota, Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0001515 opioid peptide activity; GO:0005184 neuropeptide hormone activity; GO:0031628 opioid receptor binding; GO:0048018 receptor ligand activity
  • GO BP:  GO:0007165 signal transduction; GO:0007218 neuropeptide signaling pathway; GO:0007268 chemical synaptic transmission; GO:0007270 neuron-neuron synaptic transmission; GO:0007565 female pregnancy; GO:0007600 sensory perception; GO:0019233 sensory perception of pain
  • GO CC:  GO:0005576 extracellular region; GO:0005886 plasma membrane; GO:0030425 dendrite; GO:0043025 neuronal cell body; GO:0043679 axon terminus; GO:0097060 synaptic membrane

Sequence Information

  • Sequence:  MPRVRSLFQEQEEPEPGMEEAGEMEQKQLQ
  • Length:  30
  • Propeptide:  MKVLLCDLLLLSLFSSVFSSCQRDCLTCQEKLHPALDSFDLEVCILECEEKVFPSPLWTPCTKVMARSSWQLSPAAPEHVAAALYQPRASEMQHLRRMPRVRSLFQEQEEPEPGMEEAGEMEQKQLQKRFGGFTGARKSARKLANQKRFSEFMRQYLVLSMQSSQRRRTLHQNGNV
  • Signal peptide:  MKVLLCDLLLLSLFSSVFS
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  [Nociceptin]: Ligand of the opioid receptor-like receptor OPRL1. It may act as a transmitter in the brain by modulating nociceptive and locomotor behavior. May be involved in neuronal differentiation and development.
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  OPRL1
  • Target Unid:  P41146
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-Q13519-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor006259_AF2.pdbhor006259_ESM.pdb

Physical Information

Mass: 407939 Formula: C149H238N42O53S3
Absent amino acids: CDHINTWY Common amino acids: E
pI: 3.95 Basic residues: 3
Polar residues: 3 Hydrophobic residues: 5
Hydrophobicity: -142.33 Boman Index: -9337
Half-Life: 30 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 39
Instability Index: 11874 Extinction Coefficient cystines: 0
Absorbance 280nm: 0

Literature

  • PubMed ID:  8710928
  • Title:  Structure, tissue distribution, and chromosomal localization of the prepronociceptin gene.
  • PubMed ID:  8710930
  • Title:  Primary structure and tissue distribution of the orphanin FQ precursor.
  • PubMed ID:  12950177
  • Title:  Human neutrophils as a source of nociceptin: a novel link between pain and inflammation.
  • PubMed ID:  14702039
  • Title:  Complete sequencing and characterization of 21,243 full-length human cDNAs.
  • PubMed ID:  15489334
  • Title:  The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
  • PubMed ID:  9168905
  • Title:  Solution conformation of nociceptin.